MRI-DWI 在早期大鼠肝泡球蚴病模型中的应用价值

摘要

目的：探讨 MRI-DWI 在早期大鼠肝泡球蚴病模型中的应用价值。方法对接种9 w 并经超声筛查确认接种成功的40只 SD 大鼠进行 MRI-DWI 检查，记录病灶在 MRI-T1、T2以及 DWI 图像上的特点，并与病理结果进行对照。结果早期大鼠肝泡状棘球蚴在 T1WI 图像上表现为单个或多个类圆形低信号，T2及 DWI 图像上均表现为单个或多个类圆形高信号，DWI 成像中病灶周边可见稍低于病灶内部的环形区，类似“月晕”征。病灶边缘区的 ADC 值较病灶内部及邻近正常肝组织高（P ＜0．05）。HE 染色镜下见单个或多个囊泡样红染结构，正常肝组织交界区富含微血管，伴炎性细胞浸润。结论早期大鼠肝泡球蚴病灶周边“月晕区”可作为 DWI 诊断该病较特异的依据，该区域的 ADC 值高于病灶内部及正常肝实质，经病理证实该区域为富含微血管的区域。%Objective This study was to demonstrate characteristic imaging and accurate evaluation in early stage of hepatic alveolar echinococcosis (HAE)by Diffusion-weighted MRI (DWI).Methods The early stage of experimentally induced secondary HAE in 40 rats was studied.Forty HAE lesions in 40 rats,con-firmed by Ultrasonography,were examined by MRI-T1,T2 and DWI.Results The early stage of experi-mentally induced secondary HAE presented low signal on MRI-T1,single or multiple round high signal on MRI-T2.The “halo”sign surrounding lesion was shown on DWI,and the ADC value of “halo”belt was higher than the centre of lesion and the normal hepatic tissue (P <0.05).Hematoxylin-eosin (HE)stai-ning showed that the small cyst was surrounded by the characteristically proliferated small blood vessels and infiltrated inflammatory cells.Conclusion The “halo zone”surrounding the lesions is the typical feature in DWI for the early stage of experimentally induced secondary HAE in rats,and the higher ADC value re-presented the inflammatory response belt with microvascular.