VEGF基因多态性与子宫内膜异位症遗传易感性的Meta分析

摘要

目的 探讨血管内皮生长因子(VEGF)基因-460C/T、+936C/T单核苷酸多态性(SNPs)与子宫内膜异位症遗传易感性的关系.方法 检索PubMed、Embase、中国知网和万方数字化期刊等中英文数据库,检索时间为1990年1月至2012年2月.应用Meta分析的方法分别合并这两个SNPs与子宫内膜异位症遗传易感性关系的OR值,并进行亚组分析和文献的发表偏倚检验.结果 纳入的8篇研究文献中,对于+936C/T多态,病例组共计1 784例,对照组共计1 865例,Meta分析显示:比较C等位基因携带者,携带T等位基因的妇女明显增加子宫内膜异位症的患病风险(OR=1.15,95%CI:1.01~1.30,P=0.03);对于-460C/T多态,病例组共计2 158例,对照组共计2 191例,Meta分析显示:-460C/T多态与子宫内膜异位症的发病风险无关,按照种族进行亚组分析差异也无统计学意义(P>0.05).结论 VEGF基因+936C/T SNP可能是妇女子宫内膜异位症发病风险的一个低外显率分子标志物.%Objective To explore the association between -460C/T, + 936C/T single nucleotide polymorphisms ( SNPs ) in vascular endothelial growth factor ( VEGF ) gene and the genetic susceptibility to endometriosis ( EM ). Methods The studies were identified by searching Chinese and English databases from January 1990 to February 2012, including PubMed, Embase, CNKI and WanFang Data. Meta-analysis was performed to estimate the pooled odds ratio ( OR ) to evaluate the relationship between VEGF - 460C/T, + 936C/T SNPs and the genetic susceptibility to EM. Stratified analysis was carried out according to ethnicity, and publication bias was also assessed. Results A total of 8 case-control studies were eligible for this study. With regard to + 936C/T SNP, 1 784 cases and 1 865 controls were included in total. Meta-analysis showed that compared with the C allele carriers, T allele carriers had higher risk of developing EM (0R = 1.15,95% CI: 1.01-1.30, P = 0.03). For -460C/T SNP, 2 158 cases and 2 191 controls were included in total. Meta-analysis showed that there was no association between -460 C/T SNP and the risk of EM. In addition, no significant association was observed in subgroup analysis by ethnicity ( P >0. 05 ). Conclusion VEGF + 936C/T SNP might be a low penetrance molecular marker for the risk of developing EM.