促红细胞生成素与早产儿脑白质损伤的关系研究

摘要

早产儿脑白质损伤( WMD)是神经系统伤残的主要原因之一. 影像学是WMD的确诊依据. 目前研究认为,促红细胞生成素( EPO)可促进早产儿脑发育并对脑损伤有保护作用. EPO脑保护的主要机制是抗凋亡、抗氧化、抗炎症、抗惊厥和促进脑血管新生等. 同时,EPO基因又存在多态性,可能与早产儿WMD的个体易感性差异相关联.%White matter damage ( WMD) of premature infants is one of the significant causes leading to neurological disabilities, and imaging is the way to identify the disease.Up to now, researches have found that erythropoietin ( EPO) could not only improve brain development, but have protective effect on preterm neonatal brain injury.The fundamental mechanism of EPO is its ability of inhibiting apoptosis, anti-oxidation, anti-inflammatory, anti-epilepsy, and angiogenesis.Meanwhile, there are gene polymorphisms in EPO gene, which maybe relate with the individual susceptibility difference in WMD of premature infants.