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首页> 外文期刊>Current neurovascular research >Erythropoietin Gene Polymorphism rs551238 is Associated with a Reduced Susceptibility to Brain Injury in Preterm Infants
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Erythropoietin Gene Polymorphism rs551238 is Associated with a Reduced Susceptibility to Brain Injury in Preterm Infants

机译:促红细胞生成素基因多态性RS551238与早产儿脑损伤的脑损伤降低有关

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摘要

Background: Single Nucleotide Polymorphisms (SNPs) in the Erythropoietin (EPO) promoter region have been shown to influence EPO protein expression, and high blood levels of EPO are associated with an increased risk of brain injury in very preterm infants. Here, we investigated the genotype distributions and association of three EPO gene polymorphisms (rs1617640, rs551238, and rs507392) with the risk of brain injury in preterm infants.
机译:背景:已显示促红细胞生成素(EPO)启动子区中的单核苷酸多态性(SNP)来影响EPO蛋白表达,并且高血量的EPO水平与早产儿脑损伤的风险增加有关。 在这里,我们研究了三种EPO基因多态性(RS1617640,RS551238和RS507392)的基因型分布和关联,具有早产儿脑损伤的风险。

著录项

  • 来源
    《Current neurovascular research》 |2019年第4期|共5页
  • 作者单位

    Shenzhen Univ Cent Lab Affiliated Hosp 1 Hlth Sci Ctr Shenzhen Second Peoples Hosp Shenzhen;

    Shenzhen Matern &

    Child Healthcare Hosp Dept Neonatol Shenzhen 518017 Guangdong Peoples R China;

    Shenzhen Peoples Hosp Dept Neonatol Shenzhen 518001 Guangdong Peoples R China;

    Shenzhen Longhua Peoples Hosp Dept Neonatol Shenzhen 518109 Guangdong Peoples R China;

    Shenzhen Univ Cent Lab Affiliated Hosp 1 Hlth Sci Ctr Shenzhen Second Peoples Hosp Shenzhen;

    Shenzhen Matern &

    Child Healthcare Hosp Dept Neonatol Shenzhen 518017 Guangdong Peoples R China;

    Shenzhen Peoples Hosp Dept Neonatol Shenzhen 518001 Guangdong Peoples R China;

    Shenzhen Second Peoples Hosp Dept Pediat 3002 Sungang West Rd Shenzhen 518035 Guangdong;

    Shenzhen Second Peoples Hosp Dept Pediat 3002 Sungang West Rd Shenzhen 518035 Guangdong;

    Shenzhen Univ Cent Lab Affiliated Hosp 1 Hlth Sci Ctr Shenzhen Second Peoples Hosp Shenzhen;

    Shenzhen Univ Cent Lab Affiliated Hosp 1 Hlth Sci Ctr Shenzhen Second Peoples Hosp Shenzhen;

    Shenzhen Univ Cent Lab Affiliated Hosp 1 Hlth Sci Ctr Shenzhen Second Peoples Hosp Shenzhen;

    Shenzhen Second Peoples Hosp Dept Pediat 3002 Sungang West Rd Shenzhen 518035 Guangdong;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学与精神病学;
  • 关键词

    Erythropoietin; genetic polymorphism; allele; brain injury; preterm infants; genotype;

    机译:促红细胞生成素;遗传多态性;等位基因;脑损伤;早产儿;基因型;

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