不同病理类型的宫颈癌与血清鳞状细胞癌相关抗原的关系研究

摘要

Objective To explore and analyze the association between cervical cancer of different pathological type and serum squamous cell carcinoma antigen (Scc-Ag ) .Methods Ninety patients with cervical cancer admitted in obstetrics and gynecology department of Chongqing Fuling District Central Hospital from April 2015 to April 2017 were selected and divided into cervical squamous carcinoma group (n = 45) ,cervical adenosquamous carcinoma group (n = 26) ,small cell cervical carcinoma group (n =10) and cervical adenocarcinoma group (n = 9) based on different pathological types .Serum Scc-Ag in four groups was detected using immune luminescence sandwich method .Results Proportion of patients with serum Scc-Ag concentration < 1 .5ng/mL in small cell cervical carcinoma group and cervical adenosquamous carcinoma group was higher than that in cervical squamous carcinoma group and cervical adenocarcinoma group ,and proportion of patients with serum Scc-Ag concentration ≥ 1 .5ng/mL in cervical squamous carcinoma group and cervical adenocarcinoma group was higher than that in small cell cervical carcinoma group and cervical adenosquamous carcinoma group ,and all differences were statistically significant (χ2 value ranged 6 .39 - 7 .12 ,all P <0 .05) .Serum Scc-Ag levels in four groups after treatment were lower than thsoe before treatment ,and reduction of serum Scc-Ag in cervical squamous carcinoma group after treatment was significantly greater than that in the other three groups , and all differences were statistically significant (t value ranged 2 .25 - 4 .56 ,all P < 0 .05) .Conclusion There is a correlation between Scc-Ag and pathological type of cervical cancer .Serum Scc-Ag can be used as index for cerical cancer early diagnosis and treatment effectiveness evaluation ,especially for cervical squamous carcinoma .%目的 探究与分析不同病理类型的宫颈癌与血清鳞状细胞癌相关抗原(Scc-Ag)的关系.方法 选取重庆市涪陵中心医院妇产科自2015年4月至2017年4月收治的90例宫颈癌患者,根据宫颈癌病理类型的不同分为宫颈鳞癌组(n=45)、宫颈腺鳞癌组(n=26)、宫颈小细胞癌组(n=10)、宫颈腺癌(n=9),采用免疫发光夹层法测定四组患者的血清Scc-Ag含量.结果 宫颈小细胞癌组 、宫颈腺鳞癌组血清Scc-Ag浓度<1.5ng/mL患者所占比例明显高于宫颈鳞癌组与宫颈腺癌组,宫颈鳞癌组 、宫颈腺癌组血清Scc-Ag浓度 ≥1.5ng/mL患者所占比例明显高于宫颈小细胞癌组与宫颈腺鳞癌组,差异均有统计学意义(χ2=6.39～7.12,均P<0.05).四组治疗后与治疗前相比血清Scc-Ag水平降低,宫颈鳞癌组患者治疗后血清Scc-Ag水平降低差值明显高于其他三组,差异具有统计学意义(t=2.25～4.56,均P<0.05).结论 血清Scc-Ag与宫颈癌病理类型之间存在一定的关系,血清Scc-Ag可作为宫颈癌早期辅助诊断及评价治疗效果的可靠指标,尤其对于宫颈鳞癌而言更具价值.