负性情绪对子宫内膜癌化疗妇女健康相关生活质量的影响

摘要

目的 探讨负性情绪对子宫内膜癌化疗妇女健康相关生活质量的影响.方法 以2015年12月26日至2016年10月7日在首都医科大学附属北京妇产医院肿瘤科接受术后化疗的62例子宫内膜癌患者为研究对象,使用汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HADA)和生活质量核心问卷(QLQ-C30)对患者进行调查.结果 在62例子宫内膜癌化疗患者中有焦虑症状者38例(61.29%),包括可能有焦虑18例(29.03%),肯定有焦虑14例(22.58%),肯定有明显焦虑6例(9.68%).62例子宫内膜癌化疗患者中有抑郁35例(56.45%),包括轻度抑郁21例(33.87%),中度抑郁11例(17.74%),重度抑郁3例(4.84%).30例患者同时存在焦虑和抑郁,占48.39%.焦虑和抑郁组角色功能、社会功能、躯体功能、认知功能、情绪功能评分均显著低于非焦虑和抑郁组(t值分别为3.407、3.070、2.354、2.234、3.599,均P<0.05),而疲乏、疼痛、恶心呕吐评分均显著高于非焦虑和抑郁组(t值分别为2.310、2.420、2.527,均P<0.05).结论 子宫内膜癌化疗妇女易发生负性情绪,进而影响患者的生活质量.%Objective To investigate the effect of negative emotion on health-related quality of life in women patients with endometrial cancer during chemotherapy.Methods Sixty-two patients with endometrial cancer receiving postoperative chemotherapy from December 26, 2015 to October 7, 2016 in oncology department of Beijing Maternity Hospital Affiliated to Capital Medical University were enrolled in study.Patients were assessed with Hamilton anxiety scale (HAMA), Hamilton depression scale (HADA) and quality of life questionnaire-core 30 (QLQ-C30).Results Among 62 endometrial carcinoma cases treated with chemotherapy, 38 cases had anxiety symptom (61.29%), including 18 cases suspected with anxiety (29.03%), 14 cases showing definite anxiety symptom (22.58%), 6 cases indicating obvious anxiety (9.68%).Among 62 cases, 35 cases had depression symptom (56.45%), including 21 cases of mild depression (33.87%), 11 cases of moderate depression (17.74%), and 3 cases of severe depression (4.84%).Thirty patients had both anxiety and depression, accounting for 48.39%.Role function, social function, physical function, cognitive function and emotional function scores of patients with anxiety and depression were significantly lower than those of patients without anxiety and depression (t value was 3.407, 3.070, 2.354, 2.234 and 3.599, respectively, all P<0.05), but fatigue, pain, nausea and vomit scores were significantly higher than those of patients without anxiety and depression (t value was 2.310, 2.420 and 2.527, respectively, all P<0.05).Conclusion Women with endometrial cancer receiving chemotherapy are prone to negative emotions that affects their quality of life.