Hedgehog信号调控骨髓间充质干细胞成软骨细胞分化：调控方式及其串话机制尚待研究

摘要

背景：Hedgehog 信号通路在骨髓间充质干细胞成软骨细胞分化过程中发挥重要的调控作用，但具体的调控机制，以及与其他信号通路的串话机制仍需进一步的研究，是近来研究的热点。目的：介绍hedgehog信号在调控骨髓间充质干细胞成软骨分化过程中信号转导机制的研究现状与发展趋势，以及与其他信号通路的相互串话。方法：通过搜索CNKI，PubMed及Google Scholar等数据库，以“hedgehog，骨髓间充质干细胞，软骨形成，软骨细胞”和“hedgehog，IHH，SHH，bone marrow mesenchymal stem cel ，chondrogenesis, cartilage， chondrocyte”为检索词，查阅有关hedgehog信号与骨髓间充质干细胞分化相关的文献，最终共纳入36篇文献进行综述。结果与结论：骨髓间充质干细胞是目前公认的组织工程种子细胞来源，hedgehog信号通路是运动系统发育过程中重要的信号分子。Hedgehog信号蛋白IHH和SHH参与调控骨髓间充质干细胞的增殖与成软骨分化，以及软骨形成后的表型维持，且与其他信号通路发挥协同作用。然而，具体的调控方式以及与其他信号的串话机制，仍需进一步的研究，是这一领域未来研究的方向。%BACKGROUND:The hedgehog pathway has paid an important role in the progress of chondrogenesis from bone marrow mesenchymal stem cells. However, the definite signal transduction pathway and cross-talking relationship with other common signal pathways are stil poorly understood and the researches related to this field is to continue as a hotspot in the future study. OBJECTIVE:To investigate the research progress of hedgehog signal pathway on the regulation of the chondrogenesis from bone marrow mesenchymal stem cells and the relationship between hedgehog and other signal pathways in the process. METHODS:A computer-based online search in CNKI, PubMed and Google Scholar databases was performed using key words of“Hedgehog, IHH, SHH, bone marrow mesenchymal stem cells, cartilage, chondrogenesis”in English and Chinese, respectively. Literatures related to the process of chondrogenesis from bone marrow mesenchymal stem cells were included and 36 articles were extensively summarized for review. RESULTS AND CONCLUSION:Bone marrow mesenchymal stem cells are currently accepted optimal cellseeds for the cartilage tissue engineering, and hedgehog is a critical signal molecule in the development of skeletal system. The IHH and SHH in hedgehog signal closely participate in control ing the processes of bone marrow mesenchymal stem cellproliferation and chondrogenesis, chondrocyte phenotype maintenance and cooperation with other common single pathways. However, the specific signal transduction mechanism and cross-talking contact with other signal pathways stil need to be further studied, and it stands for the future research directions.