BACKGROUND:Stem cel s have the potential to differentiate into various organs and tissues. In recent years, stem cel s have been proved to differentiate into hair fol icles under certain conditions. OBJECTIVE:To review the research progress and prospect of stem cel s differentiating to hair fol icles, thereby providing a reliable basis for clinical treatment of serious hair fol icle injury. METHODS:A computer-based search of PubMed, EMBASE, WanFang, CNKI databases was performed for related articles published between 2013 and 2015, using the keywords of“cel hair, fol icle stem, medicine regenerative, differentiation”in English and Chinese. A total of 207 articles were retrieved, and final y 34 articles were included in result analysis. RESULTS AND CONCLUSION:Stem cel s from different sources al have the ability to differentiate into hair fol icles under certain inductions. However, it is important to seek more scientific and rational methods for the differentiation of stem cel s into hair fol icles based on overcoming their own shortcomings. A great progress has been made in animal experiments and subclinical trials, and even a great breakthrough in some aspects. Further studies on combining the advantages and overcoming the shortcomings of various stem cel s during differentiation are required for the clinical treatment of serious hair fol icle injury.%背景：干细胞具有向各种器官、组织分化的潜能，近年的研究证实，在一定条件下，干细胞可向毛囊分化。目的：综述各种干细胞向毛囊分化的研究进展及应用前景，为临床毛囊严重缺损患者的治疗提供可靠的依据。 方法：应用计算机检索2013至2015年 PubMed、EMBASE等数据库相关文章，检索词为“stem cell， hair follicle，regenerative medicine，differentiation”并限定文章语言种类为English。同时计算机检索2013至2015年万方数据库和中国知网数据库，检索词为“干细胞，毛囊，再生医学，分化”，并限定文章语言种类为中文。共检索到文献207篇，阅读标题和摘要进行初筛，排除研究目的以及内容重复的研究，最终选定文献34篇。 结果与结论：研究者发现不同干细胞在一定条件下均具有向毛囊诱导分化的潜能，但仍需克服各自存在的缺陷以寻求更加科学、合理的干细胞分化为毛囊的条件和方法。在各种干细胞向毛囊分化的研究中，动物实验及亚临床试验已取得了很大进展，甚至在某些方面有重大突破，在今后的研究中结合各种干细胞分化的优点以及改善研究过程中出现的缺点，为进一步用于毛囊损伤后的临床治疗提供了坚实的基础。
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