含肟酯类姜黄素衍生物的合成及其抗病毒活性

摘要

采用生物活性因子拼接法将肟酯引入单羰基姜黄素衍生物1,5-二取代芳基-1,4-戊二烯-3-酮中,合成了11个新型不对称1,5-二取代-1,4-戊二烯-3-酮肟酯类姜黄素衍生物,其结构经1H NMR,IR和元素分析表征.初步生物活性测试结果表明,部分化合物具有一定的抗黄瓜花叶病毒(CMV)活性.%Curcumin was modified by active functional group oxime ester with biologically active factor splicing of 1,5-diphenyl-1,4-pentadien-3-one compound. Eleven novel oxime-esters of curcumin derivatives were synthesized. The structures were characterized by 1H NMR, IR and element analysis. The preliminary bioassay showed that some of them exhibited a certain inhibitory activity of antiCMV.