极光激酶抑制剂MLN8237的合成方法改进

摘要

以2-氨基-5-氯苯甲酸为起始原料,用改进方法经十步反应合成了极光激酶抑制剂MLN8237,总产率12.3％,其结构经1HNMR和MS确证.%Aurora-A kinases inhibitor MLN8237 was synthesized via a ten-steps reaction from 2-ami-no-5-chlorobenzoic acid in an overall yield of 12.3%. The structures were confirmed by 1H NMR andrnMS.