SELECTIVE EXPRESSION INHIBITOR FOR AURORA KINASE A AND AURORA KINASE B GENES

摘要

A drug containing a pyrrole-imidazole polyamide comprising an N-methylpyrrole unit (hereinafter sometimes referred to as Py), an N-methylimidazole unit (hereinafter sometimes referred to as Im) and a γ-aminobutyric acid unit which can be folded at the γ-aminobutyric acid unit to form a U-shape conformation within the minor groove in the double strand region (hereinafter referred to as the target region) containing a part of the -100 to -70 positions (SEQ ID NO:2) in the base sequence of human aurora kinase A (hereinafter sometimes referred to as hAURKA) promoter or the whole thereof and a chain that is complementary thereto, and in which the C-G base pair corresponds to the Py/Im pair, the G-C base pair corresponds to the Im/Py pair and the A-T and T-A base pairs correspond each to the Py/Py pair.