O-炔丙基-N,N-二（2-氯乙基）-4-氨基苯酚的合成

摘要

N,N-bis(2-chloroethyl)-4-aminophenol(5)was prepared by hydroxyethylation, benzyl pro-tection, chlorination and deprotection, using 4-aminophenol as the raw material. The new compound, O-propargyl-N,N-bis(2-chloroethyl)-4-aminophenol, was synthesized by O-alkylation of 5 with propar-gyl bromide in the presence of cesium carbonate. The structure was characterized by 1 H NMR, 13 C NMR and MS.%以对氨基苯酚(1)为原料,经氨基的羟乙基化、酚羟基的苄基保护、氯代、脱保护制得N,N-二(2-氯乙基)-对氨基苯酚(5)；在碳酸铯作用下,5与溴丙炔经O-烷基化反应合成了新化合物———O-炔丙基-N, N-二(2-氯乙基)-4-氨基苯酚,其结构经1 H NMR,13 C NMR和MS表征。