Pharmaceutical composition for inhibition of her-2 kinase activity, Compound, isolated maleate Monohydrate Crystal forms of (e) - N - (4 - 3 - (4 - (2 - chlorine - piridinilmetoxi) anilino - 3 - cyano - 6 - 7 - ethoxy - 4 - (dimethylamino quinolinil} 2 - / -),Maleate (e) - N - (4 - 3 - (4 - (2 - chlorine - piridinilmetoxi) anilino - 3 - cyano - ethoxy - 6 - 7 - quinolinil} - 4 - (dimethylamino) - 2 - / partially hydrated and anhydrous maleate (e) - 4 - N - {3 - Chloro - 4 - (2 - piridinilmetoxi) anilino - 3 - cyano - ethoxy - 6 - 7 - quinolinil} - 4 - (dimethylamino) - 2 - / and methods to prepare (e) - N - (4 - 3 - (4 - (2 - chlorine - piridinilmetoxi) anilino - 3 - cyano - ethoxy - 6 - 7 - quinolinil} - 4 - (dimethylamino) - 2 - butenamIda as a maleate Salt and maleate (e) - N - (4 - 3 - (4 - (2 - chlorine - piridinilmetoxi) anilino - 3 - cyano - ethoxy - 6 - 7 - quinolinil} - 4 - (dimethylamino) - 2 - / anhydrous

摘要

Forms of maleate Salt of (e) - N - (4 - [3 - (4 - (2 - chlorine - piridinilmetoxi) anilino] - 3 - cyano - ethoxy - 6 - 7 - quinolinil} - 4 - (dimethylamino) - 2 - /, Methods for preparing Crystalline forms of maleate Salt. Associated Compounds, and Pharmaceutical compositions containing the salts maleate.Maleate salts are useful in the treatment of cancer, particularly those affected by Family Kinases of the epidermal growth factor receptor.Claim 1: a method for Preparation of (e) - N - (4 - [3 - (4 - (2 - chlorine - piridinilmetoxi) anilino] - 3 - cyano - ethoxy - 6 - 7 - quinolinil} - 4 - (dimethylamino) - 2 / - as maleate Salt,Characterized by understanding the mixing Stage: (e) - N - (4 - [3 - (4 - (2 - chlorine - piridinilmetoxi) anilino] - 3 - cyano - ethoxy - 6 - 7 - quinolinil} - 4 - (dimethylamino) - 2 - / and Maleic acid in a Water alcohol Solution a high temperature. Claim: a compound characterized by 14 belong to the set that consists of a group of formula (1).