p53基因 Arg72Pro 多态性与复发性流产相关性的 Meta 分析

摘要

目的：系统地评价 p53基因 Arg72Pro 多态性与复发性流产的相关性。方法计算机检索 PubMed、Chochrane、Medline、CNKI、VIP 和 WanFang Data 数据库，搜集关于 p53基因 Arg72Pro 多态性与复发性流产相关性的研究，检索时限均为从建库至2015年12月3日。由2位研究者独立筛选文献、提取资料和评价纳入研究的偏倚风险后，采用 RevMan 5．3软件进行 Meta 分析。结果最终纳入7个病例对照研究，包括病例组991例，对照组913例。Meta 分析结果显示，p53基因 Arg72Pro 多态性与增加患复发性流产的风险相关（Pro／Pro 与 Arg／Pro ＋Arg／Arg 的OR ＝2．22，95％ CI 为1．27～3．89；Pro／Pro 与 Arg／Arg 的 OR ＝2．23，95％ CI 为1．05～4．73；Pro／Pro 与 Arg／Pro 的OR ＝1.89，95％ CI 为1．36～2．64）。结论 p53基因 Arg72Pro 多态性与复发性流产发病风险增高相关。%Objective To synthesize evidence on the correlation between p53 Arg72Pro polymorphism and recurrent spontaneous abortion. Methods PubMed,Cochrane,Medline,CNKI,VIP,and WanFang Data were searched from inception to December,2015 to collect studies on the correlation between p53 Arg72Pro polymorphism and recurrent spontaneous abortion.The studies were screened according to the predefined inclusion and exclusion criteria by two researchers independently.The quality of each report was evaluated,the data were extracted,and then meta-analysis was performed using RevMan 5.3 software. Results A total of 7 case-control studies involving 991 cases and 913 controls were identified.The results of meta-analysis showed that p53 Arg72Pro polymorphism was associated with an increased risk of recurrent spontaneous abortion (Pro /Pro vs Arg/Pro +Arg/Arg:OR =2.22,95%CI:1.27 -3.89;Pro /Pro vs Arg/Arg:OR =2.23,95% CI:1.05 -4.73;Pro /Pro vs Arg/Pro:OR =1.89,95% CI:1.36 -2.64 ). Conclusion The p53 Arg72Pro polymorphism is associated with an elevated risk of recurrent spontaneous abortion.