左外侧裂后部经颅直流电刺激对失语症动作图命名的作用

摘要

目的:前期研究结果提示左外侧裂后部周围区(PPR)阳极经颅直流电刺激(tDCS)可以提高失语症患者物体图命名能力.本研究的目的是明确左侧PPR区阳极tDCS对失语症患者动作图命名的作用.方法:采用自身对照A-B期设计.对接受2周常规语言治疗+tDCS假刺激(A期)后,动作图命名无明显变化的8例脑卒中后(＞3个月)失语症患者进行2周常规语言治疗+tDCS治疗(B期).结果:A期治疗前后动作图命名非治疗项和治疗项均无明显改善,提示患者语言功能处于“平台期”.B期治疗后较治疗前动作图命名的非治疗项和治疗项均明显改善(P＜0.05),提示动作图命名有泛化作用；动宾结构非治疗项未见明显变化,治疗项显著提高(P＜0.05).结论:对左PPR区实施阳极tDCS,可以促进失语症患者动作图命名的能力,并对动词命名有泛化作用.%Objective: The previous study suggested that transcranial direct current stimulation (tDCS) over posterior perisylvian region (PPR) could improve object picture naming in aphasic patients. The aim of present study was to investigate the effects of anodal tDCS over left PPR on action picture naming in aphasic patients after stroke. Method: An A-B design was used in this study. Conventional language treatment coupled with sham tDCS was implemented for 2 weeks (10 working days) in phase A, and the language treatment coupled with tDCS for 2 weeks in phase B. Eight aphasic patients (> 3 months post stroke) were enrolled in this study.rnResult: There was no significant change in treated and untreated items before and after phase A in the aphasic patients, suggesting their language ability reached to "plateau . The correctly named treated and untreated items of action picture naming increased significantly after phase B compared with that before phase B (P < 0.05), indicating a generalizing effect in action picture naming. The correctly named untreated items of verb-object structure did not changed, but that of treated items improved significantly after phase B (P < 0.05).rnConclusion: Anodal tDCS over the left PPR coupled with language treatment can improve action picture naming and have a generalizing effect on untreated items in aphasic patients.