Objective To investigate the effect of different chemoradiotherapy sequences and schedules on progression-free survival after surgery of high-grade glioma.Methods Eighty patients with high-grade glioma who were admitted into our hospi-tal during May 2011 and May 2013 were randomly selected and were randomized into two groups to receive chemoradiotherapy+chemotherapy and early chemotherapy+concurrent chemoradiotherapy+adjuvant chemotherapy ,respectively.Clinical efficacy of the two groups was observed ,recorded and compared.Results There were no differencs between the general data of patients in the two groups (P>0 .05).COX multiple factor analysis showed that patients'prognosis was associated with pathological grading ,KPS scores ,preoperative convulsion and tumor resection range (P<0 .05). There was no statistically significant differ-ence in CBR between the two groups after 5 months of treatment (P>0.05) ,while statistically significant difference was found after 8 months of treatment (P< 0.05). No statistically significant difference was observed in median OS between the two groups (P>0.05). Statistically significant difference was found in median PFS between the two groups (P<0.05).Conclusion Progression-free survival was effectively prolonged in patients with high-grade glioma who received early chemotherapy + concurrentchemoradiotherapy + adjuvant chemotherapy after surgery.%目的：探讨高级别脑胶质瘤术后不同放化疗时序及程序对无进展生存期的影响。方法选择我院2011-05-2013-05收治的高级别脑胶质瘤患者80例，随机分为2组，分别给予放化疗＋化疗以及早期化疗＋同步放化疗＋辅助化疗。观察记录2组临床疗效，并进行比较。结果经COX多因素分析，病理分级、KPS评分、术前抽搐、肿瘤切除范围对患者的预后存在影响（均 P＜0.05）；治疗5个月，2组CBR比较差异无统计学意义（P＞0.05）；治疗8个月，2组CBR比较差异有统计学意义（P＜0.05）；2组中位OS比较差异无统计学意义（P＞0.05）；2组中位PFS比较差异有统计学意义（P＜0.05）。结论高级别脑胶质瘤术后予以早期化疗＋同步放化＋辅助化疗可有效延长患者的无进展生存期。
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