Objective To investigate the pregnancy outcome of cervical intraepithelial neoplasia ( CIN) by loop electrosurgical excision procedure ( LEEP) , and to analyze the related factors by logistic regression.Methods Seventy-six cases of cervical intraepithelial neoplasia treated in Shanxi Provincial People's Hospital from February 2015 to January 2018 were selected as the observation group , and 76 healthy pregnant women in the same period were randomly selected as the control group .The delivery mode, pregnancy outcome and related factors of the two groups were observed and analyzed by Logistic regression analysis .Results The cesarean section rate of the observation group ( 72.4％) was higher than that of the control group (47.4％) , the natural childbirth rate of the control group (42.1％) was higher than that of the observation group (18.4％) (P all<0.05).There was no significant difference in forceps delivery between the two groups ( P>0.05 ) .The rate of premature delivery in the control group ( 5.3％) was lower than that in the observation group ( 15.8％, P<0.05 ) .There was no significant difference between the two groups in the postpartum hemorrhage , cervical laceration , total labor process or neonatal Apgar score ( P>0.05 ) .The patients with residual cervical canal length >1 cm and patients with resection volume less than 4 cm3 had better pregnancy outcomes , and the difference was significant ( P<0.05 ) .There was close relationship between the resection of tissue volume and the remaining cervical canal length .The longer the length of the uterine cervix was , the lower the risk of bad pregnancy outcome was;the greater the volume of the excised tissue was , the higher the risk of bad pregnancy outcome was .Conclusions The effect of cervix loop electrocution on the pregnancy outcome of cervical intraepithelial neoplasia is less , but it will increase the rate of caesarean section and premature delivery .The volume of tissue and the length of the remaining cervical canal are closely correlated with the outcome of the pregnancy , which can guide the safety of clinical use .%目的 探讨宫颈环形电切术(LEEP)治疗宫颈上皮内瘤变(CIN)的妊娠结局,并采用Logistic回归分析其相关影响因素.方法 选取2015年2月至2018年1月山西省人民医院收治的76例宫颈上皮内瘤变接受LEEP治疗后妊娠者作为此次研究的观察组,并随机选择同期分娩的76例健康孕妇作为对照组,观察并记录两组妊娠者的分娩方式、妊娠结局,并进行相关影响因素的Logistic回归分析.结果 观察组剖宫产率(72.4％)高于对照组(47.4％),自然分娩率(42.1％)高于观察组(18.4％),差异均有统计学意义(P均<0.05).对照组和观察组患者的产钳助产差异未见统计学意义(P>0.05).对照组的早产率(5.3％)低于观察组(15.8％),差异有统计学意义(P<0.05).两组患者的产后出血、宫颈裂伤、分娩总产程以及新生儿Apgar评分等妊娠结局比较差异未见统计学意义(P>0.05).剩余宫颈管长度>1 cm患者和切除组织体积≤4 cm3患者妊娠结局较好,差异有统计学意义(P<0.05).切除组织体积、剩余宫颈管长度与妊娠结局有密切关系:剩余宫颈管长度越长,发生不良妊娠结局的风险就越低;切除组织体积越大,发生不良妊娠结局的风险就越高.结论 LEEP治疗CIN对妊娠结局的影响较小,但会增加患者的剖宫产率和早产率.切除组织体积和剩余宫颈管长度与患者的妊娠结局有密切关系,可指导临床上安全使用.
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