乳腺癌组织中D2-40标记的淋巴管浸润与淋巴结转移的关系

摘要

Objective To investigate the feasibility of D2-40 for the detection of lymphatic and clinicopathological of lymphatic vessel invasion in breast cancer.Methods Immunohistochemistry was used to detect the expression of D2-40 in 72 cases of breast cancer and 15 cases of benigh breast tumor and lymphatic invasion,and the correlation of D2-40 expression with axillary lymph node metastasis was analyzed.Results LVI positive rate in breast cancer was 69.4 ％,it was 85.7 ％ in lymph nodepositive group,54.1％ in lymph node-negative group,the former was significantly higher than the latter(P ＜0.01) ; LVI was positively correlated with axillary lymph node metastasis(r =0.382).Conclusions D2-40 can specially mark the lymphatic vessel in breast cancer,get a better staining result,which makes it a reliable marker of lymph vessel; LVI is positively correlated with axillary lymph node metastasis and earlier than axillary lymph node metastasis,so it should be the conventional clinical pathological testing item.%目的 探讨D2-40标记乳腺癌组织淋巴管的可行性(LVI)与淋巴结转移的关系.方法 采用二步法免疫组化染色检测72例乳腺癌和15例乳腺良性病变组织中D2-40的表达及淋巴管受癌细胞浸润情况,分析其与乳腺癌腋窝淋巴结转移的关系.结果 乳腺癌组织中的LVI阳性率为69.4％,腋淋巴结转移组为85.7％,未转移组为54.1％,转移组高于未转移组,差异有统计学意义(P＜0.01);LVI与患者腋窝淋巴结转移呈正相关(r =0.382),淋巴结转移＞10个患者中LVI阳性率最高(100％),淋巴结阴性组LVI阳性率最低(54.1％).结论 D2-40可作为可靠的淋巴管标记物;LVI与乳腺癌淋巴结转移呈正相关,早于淋巴结转移出现,可作为临床病理学的检测项目.