cqvip:Previous investigations have shown that calcitonin gen-related peptide(CGRP) protects against myocardial ischemia-reperfusion injury and that rutaecarpine activates vanilloid receptors to evoke CGRP release.In the present study,SD rats were pretreated with rutaecarpine 10min before the experiment,and then the left main coronary artery was subjected to 60min occlusion followed by 3h reperfusion.Pretreatment with rutaecarpine(100 or 300μg·kg^-1,iv) significantly reduced infarce size and creatine kinase release concomitantly with a significant increase in plasma concentrations of CGPR.These effects of rutaecarpine were completely abolished by pretreatment with capsazepine(38mg·kg^-1,ic),a competitive vanilloid receptor antagonist or capsaicin (50mg·kg^-1,sc),which selectively depletes transmitters in capsaicin-sensitive sensory nerves.These results suggest that the kprotection of rutaecarpine against myocardial ischemia-reperfusion injury is due to stimulation of endogenous CGRP release via activating vanilloid receptors in rats.
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