转化毒理学研究概述

摘要

As an integral part of translational medicine,translational toxicology is intended to apply the results of toxicological studies to the prevention of diseases and the harmful effects on organisms. As far as drug safety evaluation is concerned,translational work is focused on developing more sensitive and specific translational safety biomarkers. Previous research focused on indicators of the liver and kidney,cardiovascular damage in the early stage,and detection of early-stage cancer. MicroRNA is hot sphere of research and considered a potential biomarker. Translational toxicology requires multi-discipli-nary and multi-agency communication and cooperation. The approach adopted by the Predictive Safety Testing Consortium is relatively perfect and is worth learnikng from.%作为转化医学不可分割的组成之一，转化毒理学的研究目的是将毒理学研究成果应用于疾病和有害作用的提示与防控。在药物的安全性评价方面，转化毒理学工作的重点在于寻找更优的转化性生物安全标志物。国内外研究的重点主要集中在早期心血管、肝和肾损伤以及致癌作用的提示上，微小 RNA 是有潜力成为转化性生物安全标志物的物质中比较热门的一类分子。转化毒理学工作的开展需要多学科与多机构间沟通合作。目前，预测安全检测协会的工作模式相对完善，值得学习和借鉴。本文拟以药物毒理学研究为例，对于转化医学与转化毒理学、转化毒理学的工作重心，以及预测安全检测协会及其示范性作用等方面进行综述。