Objective To explore the efficacy of prophylactic bilateral internal iliac arteries balloon occlusion in treatment of women with pernicious placenta previa complicated with placenta accreta.Methods A retrospective analysis was conducted on 41 cases of pernicious placenta previa with placenta accreta admitted to Guangzhou Women and Children's Medical Centre from January 2010 to December 2012.The study group (n=13) underwent prophylactic bilateral internal iliac arteries balloon placement before cesarean section and occlusion after delivery.The control group (n =28)received conventional haemostasis during cesarean section.The amount of blood loss and blood transfusion during the operation,the perioperative hemoglobin level,operation time and duration of hospitalization of the two groups were compared with t test or Chi square test.Results The volume of intraoperative hemorrhage of the study group was lower than of the control group [(1429±875) ml vs (4600± 2090) ml,t=6.840,P=0.000],the amount of intraoperative blood transfusion in the study group was also lower [(920±438) ml vs (3600± 1225) ml,t=10.251,P=0.000].Operation time and postoperative duration of hospitalization of the study group were shorter than those of the control group [(197±45) min vs (284±44) min,t 5.850,P=0.000; (6.7±1.3) d vs (8.2± 2.2) d,t=2.272,P=0.029].There was no statistical difference on hysterectomy rate between the two groups [11/13 vs 89％(25/28),x2=0.181,P 0.670)].In addition,two cases of reoperation,one case of pulmonary edema,two cases of coagulation disorder,one case of venous thrombosis in lower limbs,one case of renal dysfunction and pulmonary edema were reported in the control group,but none in the study group.Conclusions.Prophylactic bilateral internal iliac arteries balloon occlusion is effective in reducing intraoperative blood loss,transfusion,and relative complications in patients with pernicious placenta previa complicated with placenta accreta.%目的 探索预防性双髂内动脉球囊闭塞术在凶险型前置胎盘伴胎盘植入治疗中的作用.方法 采用回顾性分析方法.2010年1月至2012年12月,就诊于广州市妇女儿童医疗中心的41例凶险型前置胎盘伴胎盘植入患者纳入研究.13例患者在剖宫产术前行预防性双髂内动脉球囊闭塞术(双髂内动脉球囊置管+术中取胎后球囊扩张),作为研究组；另28例患者没有接受预防性双髂内动脉球囊闭塞术,作为对照组.采用两独立样本t检验及x2检验比较2组术中出血量、输血量、术前术后血红蛋白变化情况、手术时间、是否子宫切除、住院时间、相关并发症的差异. 结果 研究组术中出血量为(1429±875) ml,输血量为(920±438) ml,明显少于对照组[分别为(4600±2090) ml和(3600±1225) ml],差异均有统计学意义(t分别为6.840和10.251,P均=0.000).研究组手术时间和术后住院时间均短于对照组,差异有统计学意义[(197±45) min与(284±44)min,t=5.850,P=0.000;(6.7±1.3)d与(8.2±2.2)d,t=2.272,P=0.029].但研究组子宫切除率与对照组比较差异没有统计学意义[11 13与 89％(25/28)·x2=0.181,P=0.670].对照组中需要二次开腹手术者2例,发生肺水肿1例,凝血功能障碍2例,下肢静脉栓塞1例,同时并发肺水肿及肾功能损害1例；研究组中无一例发生以上并发症.结论 预防性双髂内动脉球囊闭塞术可减少凶险型前置胎盘伴胎盘植入患者的术中出血量、输血量及相关并发症.
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