粘着斑激酶及磷酸化粘着斑激酶在鼻咽癌中的表达及意义

摘要

目的 探讨FAK及FAKPY397在鼻咽癌中的表达及意义.方法 免疫组化方法分析32例鼻咽癌及10例鼻咽部慢性炎症组织中FAK及FAKpY397的表达.结果 FAK在鼻咽癌中有表达,主要见于肿瘤实质细胞胞浆及肿瘤间质,与鼻咽癌的临床分期与病理分化程度无相关性,与淋巴结转移相关(P<0.05).FAKpY397高表达于鼻咽癌肿瘤实质细胞胞膜,与鼻咽癌临床分期及淋巴结转移相关(P<0.05),与病理分化程度无相关性.结论 鼻咽癌中存在着FAK及FAKPY397的高表达,提示两者可能在鼻咽癌的侵袭及转移中起重要作用.%Objective To detect the expressions of focal adhesion kinase(FAK)(phosphorylation ofFAK tyrosine 397(FAKpY397)in nasopharyngeal carcinoma and its clinical significance. Methods Immunohistochemical technique was used to detect the expressions of FAK,FAKpY397 in 32 human nasopharyngeal carcinoma and 10 chronic inflammation of nasopharyngeal membrane mucosa.Results Positive expressions of FAK was found in tumor endochylema and tumor stroma,which was correlated with lymph node metastasis(P＜0.05),but not related to the differentiation degree of cancer cell and the clinical stage. FAKpY397 was only overexpreased in tumor cell membrane, which was correlated with the clinical stage and lymph node metastasis(P＜0.05),but not related to the differentiation degree of cancer cell.Conclusions In nasopharyngeal carcinoma, FAK and FAKpY397 are overexpressed, which imply that FAK,FAKpY397 play an important role of enhancement in metastasis and invasion of nasopharyngeal carcinoma..