摘要：Objective To explore the effects of a combined therapy with Biyankang Tablets (BYKT) and desloratadine on the subsets of T lymphocytes in peripheral blood and serum levels of IL-4, IL-8, FN-γ and IgE among patients with allergic rhinitis based on a clinical trial. Methods Included in this study were 83 patients with allergic rhinitis treated in our hospital from Jul. 2014 to Aug. 2016, randomly divided into a single therapeutic group (STG, n=41) and a combined therapeutic group (CTG, n=42). The cases in STG were treated by desloratadine only, and those in CTG treated by a combined therapy with desloratadine and BYKT. Both therapies were given 10 days as one therapeutic course and lasted 3 continuous courses for all cases. Before and after the continuous courses of therapies, determined were such indexes as subsets of T Lymphocytes in peripheral blood and serum levels of IL-4, IL-8, FN-γ and IgE among them. By the end of therapeutic courses, a comparative analysis was made among the cases in both groups on clinical therapeutic effects, adverse effects and all the experimental indexes to explore the implications of different therapies in such cases. Resutls As shown from the results obtained by the end of therapy, the total effective rate was 95.24% (40/42) for cases in CTG, significantly higher than that of STG (73.17%, 30/41), with obviously statistical significance between them (P<0.05). While there were no significantly statistical significances present in the differences in subsets of T lymphocytes in peripheral blood and serum levels of IL-4, IL-8, FN-γ and IgE between the two groups before treatment (P>0.05), markedly changes were seen following the treatment, with significantly elevated number of CD8+T cells (P<0.05) and decreased number of CD4+T cells as well as the ratio of CD4+T/CD8+T cells (P<0.05) in both groups of cases other than that of CD3+T cells (P>0.05). However, the change extents of these indicators were much more significant in CTG than that in STG (P<0.05). Moreover, the levels of IL-4, IL-8 and IgE were significantly lowered and that of FN-γ obviously elevated following the therapy in both groups. Also, the changed levels in them were much higher for cases in CTG than for those in STG (P<0.05). Furthermore, there was no significantly statistical significance in the incidence difference of advise effects for both groups (P>0.05). Conclusion The combined therapy with desloratadine and Biyankang Tablets can effectively reduce the serum levels of IL-4, IL-8 and IgE, lower down the ratio of CD4+T/CD8+T cells, and increase the serum level of FN-γ and the number of CD8+T cells in peripheral blood during the period of therapy for cases with allergic rhinitis, with higher efficacy and better safety for such a condition.%目的 观察鼻炎康片联合地氯雷他定对变应性鼻炎患者外周血T细胞亚群及血清IL-4、IL-8、FN-γ、IgE水平的影响.方法 我院2014年7月~2016年8月收治的83例变应性鼻炎患者随机分为两组,包括中单一组41例,仅予地氯雷他定治疗;联合组42例,予地氯雷他定加鼻炎康片治疗.10天为1疗程,连续治疗3疗程.比较观察治疗前后两组患者症状,检测外周血T淋巴细胞亚群CD3+、CD4+及CD8+T细胞、CD4+/CD8+T细胞比值,血清IL-4、IL-8、FN-γ、IgE水平.疗程结束后,比较分析两组患者疗效及各项检测值.结果 联合组总有效率95.24%(40/42),明显高于单一组的73.17%(30/41),P<0.05.两组患者治疗前外周血T细胞亚群及相关比值、细胞因子与TgE水平比较P>0.05.治疗结束后,两组CD3+T细胞水平均无明显变化,但CD8+T细胞水平升高,CD4+/CD8+T细胞比值、CD4+T细胞水平均下降,但联合组CD8+T细胞水平明显高于单一组,CD4+/CD8+T细胞比值、CD4+T细胞水平则均低于单一组(P<0.05);两组血清IL-4、IL-8、IgE水平均下降,FN-γ水平上升,但联合组IL-4、IL-8、IgE水平明显低于单一组,FN-γ水平明显高于单一组,P均<0.05.两组不良反应发生率比较P>0.05.结论 地氯雷他定联合鼻炎康片疗法可有效降低变应性鼻炎患者血清IL-4、IL-8、IgE水平及外周血CD4+T细胞数与CD4+/CD8+T细胞比值,提高FN-γ和CD8+T细胞水平,效果更为显著而且安全性高.