成人阻塞性睡眠呼吸暂停低通气综合征患者临床症状和生活质量的研究

摘要

Objective To evaluate the effect of uvulopalatopharyngoplasty or continuous positive airway pressure on symptoms and quality of life in patients with obstructive sleep apnea syndrome (OSAS). Methods Forty-four patients with OSAS were surveyed before and 3months after,treatment by using ESS and SAQLI. Results The symptoms and quality of life of patients with OSAS treated by UPPP or CPAP were markedly improved(P<0.05). There was significant statistically correlation between SAQLI and AHI,LSaO2 before treatment. CPAP can improve sleepiness symptoms more than UPPP. And both of them showed similar effect in quality of life(P>0.05) Conclusion Adult OSAS had severely influence in quality of life. The treatment of UPPP and CPAP can validly improve symptoms and quality of life for patients. There was significant correlations between SAQLI and the objective data, which can be a valuable measurement in clinical diagnosis and follow-up.%　　目的探讨悬雍垂腭咽成形术（uvulopalatopharyngoplasty,UPPP）或经鼻持续正压通气（continuous positive airway pressure,CPAP）治疗方法对成人阻塞性睡眠呼吸暂停低通气综合征（obstructive sleep apnea hypopnea syndrome,OSAHS）患者症状和生活质量的影响。方法通过Epworth嗜睡量表(Epworth sleepiness scale,ESS)和睡眠呼吸暂停生活质量指数（the Sleep Apnea Quality of Life Index,SAQLI）量表对44例OSAHS患者治疗前及治疗后3月进行两次问卷调查评估。结果 OSAHS患者经UPPP或CPAP治疗后症状和生活质量较治疗前明显提高(P＜0.05)；治疗前SAQLI评分与呼吸暂停低通气指数（apnea hypopnea index,AHI）、最低血氧饱和度(LSaO2)存在明显相关性；CPAP改善患者的嗜睡症状较UPPP好，在改善患者生活质量方面两者相似(P＞0.05)。结论成人OSAHS严重影响患者的生活质量，UPPP和CPAP这两种治疗方法均能改善患者症状并能提高其生活质量；SAQLI与客观检测之间存在明显的相关性，可作为成人OSAHS患者临床诊断和疗效的评价指标。