女性 Graves 病患者血清 Ghrelin 与骨密度的关系

摘要

Objective To investigate the relationship between serum ghrelin level and bone mineral density ( BMD) in woman with Graves disease.Methods Eighty female patients with Graves disease were divided into group OP1 ( 38 cases, with osteoporosis) and group OP2 (42 cases, without osteoporosis).Twenty-five healthy female people without Graves disease and osteoporosis were chosen as control group ( group N).The serum levels of ghrelin, FT3, FT4, and TSH in all groups were detected.BMD of the lumbar vertebrae and the femur was determined using dual-energy X-ray absorptiometry.The correlation between ghrelin and BMD was analyzed.Result The serum levels ghrelin in group OP1 and group OP2 were significantly different with those in group N ( P<0.05) .But no difference of the serum levels of ghrelin between group OP1 and group OP2 was observed ( P >0.05 ) .The serum ghrelin level in group OP1 and group OP2 showed no correlation with BMD of the lumbar vertebrae and the femur ( P>0.05) .Conclusion The serum ghrelin level in woman with Graves disease is not correlated with BMD of the lumbar vertebrae and the femur.%目的：研究女性Graves病患者血清Ghrelin与骨密度（ BMD）的关系。方法80例女性Graves病患者，合并骨质疏松（ OP）组38例（ OPl组）、骨含量正常组42例（ OP2组），健康女性对照组25例（ N组），测血清Ghrelin、FT3、FT4、TSH，并测量腰椎和股骨BMD。结果（1）OPl、OP2组与N组比较，Ghrelin的水平差异有统计学意义（P＜0．05）；（2）OPl、OP2组Ghrelin水平无明显差异（P＞0．05）；（3）OPl、OP2组中Ghrelin与股骨BMD、椎骨BMD均无关（P＞0．05）。结论合并OP患者血液中Ghrelin水平与股骨BMD、椎骨BMD间无相关性。