建立骨质疏松症 iPS 细胞的重要性及其应用前景

摘要

Osteoporosis ( OP) is a complex disease characterized by descending of bone strength and increasing of bone fracture risk, which is associated with genetic and environmental factors.Currently the incidence of osteoporosis has risen year by year, which severely influences the health of the elderly.However, the pathogenic mechanism of OP is not clear, and there still remain many problems in drug therapies, such as long treatment cycle, high cost, and many adverse drug effects.Recently the emergence of induced pluripotent stem ( iPS) cells creates a novel platform for OP.It is reported that iPS cells have been successfully used in Parkinson’ s disease, Alzheimer’ s disease, Schizophrenia, spinal cord injury and so on.Modeling the osteoporosis with iPS cells will help to make some vital breakthroughs in the research of pathogenic mechanism and drug screening.This review describes the importance of modeling the osteoporosis with iPS cells and predicts its potentials in the basic experimental research and clinical treatment.%骨质疏松症（ osteoporosis， OP）是一种以骨强度下降、骨折危险性增加为特征，受遗传和环境因素共同作用的复杂疾病。目前OP的发病率逐年升高，严重影响了老年人的健康。然而由于发病机制尚不明确，药物治疗还存在周期长、费用高、不良反应多等问题。近年来诱导多功能干细胞（ induced pluripotent stem cells， iPS细胞）技术的诞生为OP的防治开创了新平台。研究报道iPS细胞模型已成功用于帕金森病、阿尔茨海默症、精神分裂症、脊髓损伤等众多疾病，建立OP的iPS细胞模型将有助于在其致病机制研究和药物筛选中取得新突破。这篇综述主要介绍建立OP的iPS细胞模型的重要性，并预测它在OP的基础研究与临床治疗上的应用前景。