重视基于片段的药物发现技术

摘要

基于片段的药物发现(FBDD)是将结构生物学、药物筛选、药物化学和分子模拟相整合的创制小分子药物的综合技术.本文简要介绍了FBDD的基本原理,并讨论了国外应用此技术推动新药研发的实例,旨在呼吁我国的众多药物研发大平台重视FBDD技术并加以应用.%The fragment-based drug discovery(FBDD) is a comprehensive technology,consisting of structural biology,drug screening,medicinal chemistry,and molecular modeling.This overview concisely describes the basic principle of FBDD method and illustrates a few examples appealing to applying this method in China Drug innovation.