STRUCTURE-BASED SCREENING TECHNIQUES FOR DRUG DISCOVERY

摘要

The invention relates to novel non-naturally occurring cell surface receptoranalogs, ligand analogs and nucleic acids encoding them. The invention furtherprovides methods for screening of ligand analogs and bioactive agents capableof modulating the signaling activity of a non-naturally occurring cell surfacereceptor analog or capable of binding to a non-naturally occurring cellsurface receptor analog.