白念珠菌White-Gray-Opaque表型转换系统的研究进展

摘要

白念珠菌是人类常见的条件致病菌, 而表型转换是其重要的生物学特性, 各个表型在宿主适应、感染、毒力及不同生活阶段发挥着不同作用.White-Gray-Opaque表型转换是白念珠菌的一种新型转换系统, 该文从White-Gray-Opaque表型特点、影响表型转换的调控因素、表型与宿主的相互作用等方面综述近年来白念珠菌在该表型系统中的研究进展, 希望通过理解其形态调节的机制以寻找感染治疗的新策略.%Candida albicans is a common opportunistic fungal pathogen of humans.An important biological feature of this fungus is its phenotypic transition, and diverse morphological phenotypes play distinct roles in host adaptation, infection and virulence during different life stages.White-Gray-Opaque phenotypic switching system is a novel phenotypic transition in Candida albicans.In this review, research achievements about this phenotypic transition were mentioned, including the traits of White-Gray-Opaque phenotype, the key regulatory factors and the interaction with hosts.In a nutshell, understanding about the molecular mechanisms of this phenotypic transition in Candida albicans might be beneficial to the discovery of novel infection treatment strategies.