硝酸舍他康唑乳膏治疗婴幼儿念珠菌性皮炎的疗效观察

摘要

目的：观察硝酸舍他康唑乳膏治疗婴幼儿念珠菌性皮炎的临床疗效和安全性。方法入选26例0～3岁念珠菌性皮炎的患儿，均经临床表现及真菌学检查确诊，外用硝酸舍他康唑乳膏2次／ d，连续7～14 d，观察其临床疗效及治疗前后真菌学变化。结果26例患儿治疗7 d 临床评分均值由6分下降至1．35分，下降幅度超过75％。治疗7 d 临床痊愈率为57．69％，有效率为92．3％，真菌学阴转率为88．46％；14 d 临床痊愈率为92．3％，真菌学阴转率为92．3％。停药后第14天随访痊愈患儿91．67％未见复发。仅1例患儿出现不良反应。结论硝酸舍他康唑乳膏治疗婴幼儿皮肤念珠菌病安全、有效，不良反应少，值得临床推广。%Objective To investigate the clinical efficacy and safety of sertaconazole cream on infant suffering from dermatitis candidiasis.Method Twenty⁃six patients with clinical and mycological diagnosis of dermatitis candidiasis were enrolled. Patients were treated with twice daily applications of sertaconazole cream for 14 days and were followed⁃up for 2 further weeks.Results Twen⁃ty⁃two Candida albicans and four non⁃Candida albicans were isolated in twenty⁃six infants.The treatment evaluation after 7 days treat⁃ment showed that more than 75% of average signs decreased from 6 to 1.35.There was a total clinical cure in 57.69%,improvement in 92.3% and mycological cure in 88.46% after 7 days treatment.At the time of 14 days follow⁃up,there was a total clinical and myco⁃logical cure in 92.3%.91.67% cure infants had not recurred at the end of the follow⁃up period.There was side effect in only one pa⁃tient.Conclusions Based on its safety and effectiveness,sertaconazole cream may be considered a new alternative for infant dermati⁃tis candidiasis treatment.