2型糖尿病家系一级亲属代谢综合征危险因素的分析

摘要

Objective:To analyse the incidence rate and risk factors of metabolic sydrome in the first degree relatives of type 2 diabetes patients. Methods:First degree relatives of type 2 diabetes patients from 41 diabetes mellitus pedigree were selected as study group(n=98),and first degree relatives without diabetes familial history of their spouses were selected as control group(n=85).High、waist circumference、weight、blood pressure、fasting and 2-hour postprandial blood glucose,tirglyceride,high dersity lipoprotein-cholesterol were measured in two groups,OGTT were measured in those without diabetes.Results:The incidence rate(32.65%) of metabolic sydrome in the first degree relatives of type 2 diabetes patients was significantly higher than that of the first degree relatives of healthy people(12.94%)χ2=9.8365,P<0.01.Central obesity、the familial history of type2 diabetes、diabetes mellitus、hipertension、dyslipidemia was closely related to metabolic sydrome. Conclusion:First degree relatives of type 2 diabetes patients are the high risk populations of metabolic sydrome.central obesity、the familial history of type2 diabetes、diabetes mellitus、hypertension、hyper-tirglyceridemia,low level of high dersity lipoprotein-cholesterol are the high risk factors of metabolic sydrome.%目的：：分析2型糖尿病家系一级亲属同胞的代谢综合征发病率及各危险因素情况。方法：以41个2型糖尿病家系中同胞一级亲属为研究组(n＝98)，以同胞配偶中无糖尿病家族史的一级亲属同胞为对照组(n＝85)。测定身高、腰围、体重、血压、空腹血糖、餐后2小时血糖、甘油三酯、高密度脂蛋白胆固醇，非糖尿病者行口服葡萄糖耐量试验。结果：2型糖尿病家系一级亲属同胞的代谢综合征的患病率(32.65%)，显著高于无糖尿病家族史的一级亲属同胞(12.94%)χ2＝9.8365 P<0.01。中心性肥胖、糖尿病家族史、糖尿病、高血压、血脂异常与代谢综合征密切相关(均P<0.05)。结论：2型糖尿病家系一级亲属是代谢综合征的高危人群。中心性肥胖、糖尿病家族史、糖尿病、高血压、高甘油三酯血症、高密度脂蛋白胆固醇降低是代谢综合征的重要危险因素。