PurposeTo investigate the multi-slice spiral CT features of lung primary invasive mucinous adenocarcinoma, a rare malignancy with few relevant literature. Materials and Methods Forty-one patients with pathology proven primary invasive mucinous adenocarcinoma of the lungs underwent MSCT examination, of which 27 patients received intravenous contrast. Imaging features were analyzed, and the patients were divided into groups according to morphology, density and enhancement.Results For 41 patients, 40 cases had one lesion, and one case had more than one lesion; the lesions were in the right upper lobe in 5 cases, right middle lobe in one case, right lower lobe in 17 cases, left upper lobe in 5 cases, and left lower lobe in 12 cases. There was solitary lesion in 40 cases. The other patient had multiple lesions. 29 cases showed nodules/masses, while non-mass lesions in 12 cases. Ground glass opacity was seen in 4 cases, single consolidation in 11 cases, and mixed consolidation in 26 cases. There was significant contrast enhancement in nodules/masses compared to non-mass lesions (t=5.00, 6.51 and 14.06,P<0.05).Conclusion MSCT shows a diversity of imaging features of primary invasive mucinous adenocarcinom, including single round lesion, lower lobe in both side; the density is lower than muscle on CT scan, and presents mild to moderate enhancement on enhancement scan round lesions has high density and enhancement range than irregular-shaped lesions.%目的：原发性肺浸润型黏液腺癌极少见，相关文献报道较少，本文探讨其多层螺旋CT（MSCT）表现，提高对本病的认识。资料与方法回顾性分析41例经手术或穿刺病理证实为原发性肺浸润型黏液腺癌患者的临床资料，所有患者行MSCT平扫，其中27例行CT增强扫描。分析病灶数量、分布、形态、密度，测量病灶主体密度和强化幅度，比较不同类型的病灶扫描前后CT值和增强幅度的差异。结果41例患者病灶数量：单发40例，多发1例。单发病灶分布：右肺上叶5例、中叶1例、下叶17例，左肺上叶5例、下叶12例；多发病灶1例（左肺下叶、右肺上叶、中叶、下叶）。形态：圆形（类圆形）29例，不规则形12例。密度：磨玻璃密度4例，单纯实变密度11例，混合实变密度26例。圆形（类圆形）病灶的扫描前后CT值、增强幅度均高于不规则形病灶，差异有统计学意义（t=5.00、6.51、14.06，P<0.05）。结论原发性肺浸润型黏液腺癌MSCT征象以单发圆形（类圆形）病灶、双肺下叶、混合实变密度多见，实性病灶平扫密度低于肌肉，增强扫描呈轻度至中度异常强化，圆形（类圆形）病灶比不规则形病灶密度高，强化幅度大。
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