FXYD6基因遗传多态性在精神分裂症患者核心家系中的传递不平衡检验

摘要

Objective To study the association between the single nucleotide polymorphisms (SNPs) in FXYD6 gene and schizophrenia in a family-trios population. Methods Six SNPs (rs10790212,rs11544201,rs555577,rs1815774,rs4938446 and rs497768) in the FXYD6 gene were genotyped by allele-specific PCR method in 101 nuclear families,and transmission disequilibrium test (TDT) was performed.Results SNPs rs10790212 and rs11544201 showed significant association with schizophrenia (P＜0.05).Furthermore,significant association of schizophrenia with the haplotype rs10790212-rs11544201 was found (P＜0.05).Conclusion FXYD6 gene might play an important role in schizophrenia susceptibility and functional analysis of FXYD6 are needed.%目的 探讨FXYD6基因单核苷酸多态性(single nucleotide polymorphisms,SNP)和精神分裂症(schizophrenia)之间的相关性.方法 采用等位基因特异性PCR的方法对FXYD6基因6个SNPs(rs10790212、rs11544201、rs555577、rs1815774、rs4938446和rs497768)位点的基因型在101个三口之家中进行传递不平衡检验(transmission disequilibrium test,TDT).结果 遗传标记rs10790212和rs11544201显示了显著的传递不平衡(P＜0.05),而单倍型分析的结果表明单倍型rs10790212-rs11544201与精神分裂症显著性关联(P＜0.05).结论 FXYD6基因与中国汉族人群精神分裂症遗传易感性相关,有必要进一步开展对FXYD6基因的功能学研究.