FISH检测t(11;14)对于七例不典型套细胞淋巴瘤的诊断意义

摘要

目的 探讨7例不典型套细胞淋巴瘤(mantle cell lymphoma,MCL)的临床特点与诊断.方法 对7例因免疫表型积分为4分而误诊为慢性淋巴细胞白血病(chronic lymphocytic leukemia,CLL)的MCL患者的临床特点和诊断进行回顾.结果 7例患者中浅表淋巴结肿大但难以触及者6例.所有患者均因广泛浸润骨髓被分为Ⅳ期,CLL免疫表型积分为4分,间期荧光原位杂交检测t(11;14)均为阳性.结论 部分MCL患者临床表现与CLL相似,间期荧光原位杂交检查将有助于其诊断.%Objective To study the clinical features and diagnosis of 7 patients with atypical mantle cell lymphoma (MCL).Methods The 7 MCL patients were misdiagnosed as chronic lymphocytic leukemia (CLL) due to a score of 4 for their immunophenotypes.The clinical features and diagnosis of such patients were retrospectively analyzed.Results Six patients had superficial lymphadenectasis but their lymph nodes could not be palpated.All 7 patients were as stage Ⅳ considering bone marrow infiltration.Scores of immunophenotype of CLL were 4,and interphase fluorescence in situ hybridization (FISH) for t(11;14)were positive in all patients.Conclusion Some MCL patients have clinical features similar to CLL.Interphase FISH can play an important role in the diagnosis of MCL.