Background and objectivehTe clinical course of pulmonary hypertension (PH) is one of progressive deterioration interspersed with episodes of acute decompensation. It is diffcult to predict when patients will die because death may come either suddenly or slowly due to progressive heart failure. hTe aim of this study is to investigate morphology, func-tion and hemodynamics in PH, compared with healthy people, and to investigate the clinical value of detection of PH by use of cardiac magnetic resonance (CMR) parameters.MethodsCMR was performed in 56 PH patients collected from Tianjin Medical University General Hospital from January 2012 to December 2014 and 22 healthy controls. hTe following parameters were calculated: right ventricle (RV) end-diastolic volume (EDV), end-systolic volume (ESV), ejection fraction (EF), myocar-dial mass (MM), RV fractional area change (RVFAC), interventricular septal curvature (CIVS), letf ventricular free wall curva-ture (CFW), and CIVS/CFW, main pulmonary artery (MPA) positive peak velocity, maximal area, minimal area and distensibility. Comparisons of CMR measurements between PH patients and controls were analyzed by using the studentt-tests. Receiver operating characteristic (ROC) curve analysis was used to compare the PH diagnostic abilities for four parameters (MPA posi-tive peak velocity, distensibility, curvature ratio, and RVFAC) and combined CMR parameter.P<0.05 was considered signiif-cant.Results Compared with healthy controls, RV morphology, function and hemodynamics of PH group declined and dete-riorate obviously. hTe ROC curve analysis showed that among the four parameters distensibility of MPA had the highest AUC value (AUC=0.95). Additionally, combined CMR parameter (positive peak velocity+distensibility+curvature ratio+RVFAC) had even higher AUC (AUC=0.988).ConclusionComprehensive CMR parameters is conducive to accurately relfect the overall state RV-pulmonary circulation in patients with PH.%背景与目的肺高血压（pulmonary hypertension, PH）临床病程表现为进行性恶化和间断急性失代偿发作，死亡可突然或缓慢发生，而临床医生往往对病情的进展评估不足。本研究旨在应用心脏核磁共振（cardiac magnetic resonance, CMR）评估PH患者右心室（right ventricle, RV）形态、功能及主肺动脉（main pulmonary artery, MPA）血液动力学，并与健康人对照，探讨CMR在检出PH中的临床应用价值。方法对56例PH患者及22例健康志愿者进行CMR扫描并获得RV舒张末期容积（end-diastolic volume, EDV）、收缩末期容积（end-systolic volume, ESV）、射血分数（ejection fraction, EF）、心肌质量（myocardial mass, MM）、RV面积变化分数（RV fractional area change, RVFAC）、室间隔与左室游离壁曲率比，MPA正向峰值流速、最大截面积、最小截面积及顺应性。PH组与对照组测量结果采用两独立样本t检验进行比较。受试者工作特征曲线（re-ceiver operating characteristic curve，ROC曲线）用于比较MPA正向峰值流速、顺应性、曲率比、RVFAC单项指标及综合评估检出PH的效能。P<0.05为差异有统计学意义。结果与对照组相比，PH组RV形态改变、功能明显下降，血液动力学指标恶化。顺应性对检出PH的效能较高（AUC为0.950）；综合应用正向峰值流速、顺应性、曲率比和RVFAC时，检出PH的效能最高（AUC为0.988）。结论 CMR综合评估指标有利于准确反映PH患者RV-肺循环整体状态。
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