近年研究证实慢性乙型肝炎(CHB)患者血清中仅存在一种HBV RNA,即长度为3.5 kb的前基因组RNA (pgRNA).pgRNA由感染肝细胞中的共价闭合环状DNA (cccDNA)产生,而cccDNA与HBV复制及感染的状态有关,因此推断pgRNA与CHB患者体内病毒复制活性相关.这对指导治疗CHB,预防肝硬化和肝癌的发生有重要意义.本文旨在对近年来有关HBV RNA的来源、性质、存在方式及临床意义等进展进行综述.%Recently,it has been proved that there is only one kind of hepatitis B virus RNA (HBV RNA) in the serum of patients with chronic hepatitis B (CHB)—pregenomic RNA (pgRNA),whose length is 3.5 kb.The pgRNA is produced by covalently closed circular DNA (cccDNA) in infected hepatocyte cells,and cccDNA is related to the replication and infection of hepatitis B virus (HBV).Therefore,we concluded that the pgRNA is associated with the activity of virus replication in patients with CHB,which is of great significance in guiding the treatment of CHB and preventing the occurrence of liver cirrhosis and liver cancer.This article aims to make a review of HBV RNA,which concluded the source,nature,existence form and clinical significance of HBV RNA in recent years.
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