目前,移植已经成为解决许多终末期疾病的重要方法,伴随移植而来的则是长期的免疫抑制剂的使用,因免疫抑制剂具有较窄的治疗指数,常需进行药物浓度监测.药物基因组学是一门研究基因与药物代谢关系的一门学科,为免疫抑制剂在不同个体达到靶浓度治疗方案的设定提供了重要帮助,同时有利于个体化治疗的实现.本文就免疫抑制剂的药物基因组学最新研究进展展开综述,以期对临床治疗提供帮助.%At present,transplantation has been the predominant way to solve most of the end-stage diseases,ensued by the use of immunosuppressive drugs.Since the immunosuppressive drugs have narrow therapeutic index,the blood drug concentration is needed to mornior.Pharmacogenetics is one subject which focuses on the interaction between gene and the metabolism of the drug,providing great help for designing the regime of achieving the target drug concentration.Meanwhile,it facilitates the realization of individual therapy.This review thus focuses on the latest advancement on the pharmacogenetics of those immunosupprressants,hoping to provide help for the treatment.
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