In vitro method to inhibit the function and / or proliferation of a janus tyrosine kinase 3, in vitro test method to assist in the identification of substances that are useful as therapeutic immunosuppressants, in vitro method to assist in the identification of a new immunosuppressant drug, in vitro to inhibit the function and / or proliferation of a cell expressing janus tyrosine kinase 3, use of at least one compound, isolated or purified chemical compound and pharmaceutical composition

摘要

"IN VITRO METHOD TO INHIBIT THE FUNCTION AND / OR PROLIFERATION OF A TYROSOS KINASE 3 JANUARY, IN VITRO TEST METHOD TO HELP IDENTIFICATION OF SUBSTANCES THAT ARE USEFUL AS IMUNOSPHERE THERAPEUTIC IMPUNIUS IMUNOSUPRESSORS, IN VITRO METHOD FOR INHIBITING THE FUNCTION AND / OR PROLIFERATION OF A CELL BY EXPRESSING JANUS TYROSIN KINASE 3, USE AT LEAST ONE COMPOUND, ISOLATED OR PURIFIED CHEMICAL COMPOUND, AND PHARMACEUTICAL COMPOSITION ". Methods for inhibiting or disrupting function-dependent Janus tyrosine kinase 3 (Jak3) are described, especially for blocking lymphotic proliferation and function (eg, T-cells, B-cells). . A Mannich base compound, or derivative or modified compound, which is capable of selectively inhibiting Jak3, while affecting other protein tyrosine kinase activities to a lesser extent or not at all, is employed to provide beneficial effects such as rejection mitigation. transplantation and relief of allergic responses, with fewer side effects than with conventional immunosuppressive agents.