循环肿瘤细胞检测新进展及临床价值

摘要

循环肿瘤细胞（ CTCs）检测具有非侵入性、采样方便、便于实时检测的特点。目前发展了多种基于物理特性和化学特性分离鉴定的CTCs检测方法，而细胞亚群分类、单细胞测序、体外培养等后续特征分析也丰富了我们对CTCs的认识和对肿瘤异质性的理解。 CTCs检测在肿瘤的早期诊断、疗效评估、预后等研究中有着非常重要的应用价值。（中华检验医学杂志，2016，39：565－567）%Circulating tumor cell ( CTC ) testing is characterized by its invasiveness, sampling convenience and facility for real-time monitoring.The booming detection technologies based on physical or immunological features, as well as the subsequent molecular analysis of CTCs including subtype classification, single cell sequencing and in vitro culture, has greatly enriched our comprehension of CTCs and cancer heterogeneity.Meanwhile, a great of researches have demonstrated the significance of CTCs testing in the clinical practice of cancers involving aspects of early diagnosis, treatment monitoring and prognosis.