18F-FDG PET-CT对滤泡性淋巴瘤诊断及预后评估的作用

摘要

目的 评估18氟-氟代脱氧葡萄糖-正电子发射计算机断层显像(fluorine-18 fluorodeoxyglucose positron emission tomography,18F-FDG PET/CT)对滤泡性淋巴瘤(follicular lymphoma,FL)患者的诊断及预后的预测价值.方法 回顾分析2005年4月至2009年7月我院收治67例初治滤泡性淋巴瘤患者,分别与6周期CHOP±R方案化疗前后行PET/CT检查,评价其对临床分期及预后评估的价值.结果 PET/CT对初始分期准确度较CT高,可获得更精确的FLIPI评分.6周期治疗结束后PET/CT阴性者与阳性者的中位PFS分别为45个月及19个月(P=0.0007),显示治疗后PET/CT检查结果为患者预后的预测指标.结论 PET-CT是FL明确分期及预后评估的可靠方法.%Objective To assess the evaluation of positron emission tomography/computed tomography in staging and prognosis in follicular lymphoma. Methods A retrospective study was performed on 67 patients with untreated biopsy-proven follicular lymphoma who underwent 18 F-fluorodeoxygulucose PET/CTCFDG PET/CT) before and after CHOP ±R induction treatment from April 2005 to July 2009. Results Initial PET/CT makes Follicular Lymphoma International Prognostic Index score more accurately than CT. In addition, post-treatment PET/CT was able to predict patients' outcomes. The median progression-fress survival was 45 months in the PET/CT negative group as compared with 19months for the group with residual uptake(P = 0. 0007). Conclusion PET/CT is useful for staging and assessing the prognosis of patients with follicular lymphoma