AFP、AFP-L3、GP73联合检测对原发性肝癌的诊断价值

摘要

目的：探讨甲胎蛋白（AFP）、甲胎蛋白异质体-L3（AFP-L3）、高尔基体蛋白73（GP73）在原发性肝癌的诊断价值。方法采用酶联免疫吸附法和电化学发光法检测68例原发性肝癌、49例良性肝病及68例健康体检者血清中 AFP、AFP-L3、GP73的含量，并进行比较。结果原发性肝癌患者组血清 AFP、AFP-L3、GP73含量明显高于良性肝病及健康对照组（P ＜0．05和 P ＜0．01）；三者联合检测的特异度和敏感度优于单独检测，所得数据有统计学意义。结论AFP、AFP-L3、GP73联合检测可明显提高原发性肝癌诊断的敏感性和特异性。%Objective To investigate the application value of detection AFP,AFP-L3 and GP73 in the diagnosis of hepatocellular carcinoma.Methods Enzyme-linked immunosorbent assay (ELISA)was adopted to detect AFP、AFP-L3 and GP73 level of senum in hepatocellular carcinoma patients(68cases),benign liver disease (49 cases)and healthy people (68cases),and comparison was done.Results the Serum AFP,AFP-L3 and GP73 level in hepatocellular carci-noma were significantly higher than those of patients with benign liver diseases and control group (P < 0.05,P <0.01).The specificity and sensitivity of the combined detection of the three was better than that of the individual test, and the difference was statistically significant.Conclusion Combination test of serum AFP,AFP-L3 and GP73 has good diagrnosis value for hepatocellular carcinoma.