皮下注射长效罗哌卡因对伤口愈合的影响

摘要

Objective To compare the effects of single subcutaneous injection of long-acting ropivacaine injection with ropivacaine hydrochloride on local skin wound healing.Methods Bama miniature pig 12, male and femaleeach half.After routine disinfection, each pig cut 5wounds on the back, about 2cm×2cm in size, numbered 1-5.Randomly divided into 0.3％long-acting ropivacaine injection (R1), 0.5％long-acting ropivacaine injection (R2), 0.3％ropiva-caine injection(R3), 0.5％ropivacaine injection Liquid(R4), without any treatment(R5).Take the wound and its sur-rounding skin and subcutaneous tissue into 10％neutral buffered formalin solution for fixed, routine paraffin embed-ding, slicing and HE staining.Microscopy Histopathology examination.Results There was no significant difference be-tween the two groups at R1and R3, R2and R4in the incision area on the 7th and 14th days(P＞0.05), and the differ-ence between the two groups was statistically significant(P＜0.05).The results of pathological examination showed that wound granulation tissue proliferation was more obvious, the number of blood vessels increased, epidermal cells appeared earlier and wound healing time was shortened.Similarly, on the 7th and 14th days, histopathological score(P＞0.05 ).There was difference in histopathological score between group R5and group R5 (P＜0.05).Conclusion Long-term ropivacaine injection can promote the healing of wounds in single subcutaneous injection of wound infiltration anesthesia.And ropivacaine hydrochlo-ride injection contrast, the two on the local skin wound healing no significant difference.%目的 对比观察长效罗哌卡因注射液单次皮下注射与盐酸罗哌卡因给予小型猪对局部皮肤创伤愈合影响的差异.方法 巴马小型猪12只,雌雄各半.在常规消毒之后,每只 猪背部各切割5个创面,大小约2cm×2cm,编号为1-5.随机分为0.3％ 长效罗哌卡因注射液(R1),0.5％ 长效罗哌卡因注射液(R2),0.3％ 罗哌卡因注射液(R3),0.5％ 罗哌卡 因注射液(R4),不做任何处理(R5).取创面及其周围皮肤及皮下组织放入10％中性缓冲福尔马林溶液中进行固定,进行常规石蜡包埋、切片制作与HE染色.显微镜进行组织病理学的检查.结果 R1与R3、R2与R4两组对比在第7天和第14天的切口面积、切口上皮化完全愈合的时间无差异(P＞0.05),与R5比较差异有统计学意义(P＜0.05);病理检查结果显示:创面肉芽组 织增生愈发明显,血管数量增多,表皮细胞提前出现,创口愈合所需时间缩短;同样前四组第7天和第14天的组织病理学评分无差异(P＞0.05),与R5组相比组织病理学评分有差异(P＜0.05).结论 长效罗哌卡因注射液单次皮下注射伤口浸润麻醉时可以促进伤口的愈合.且与盐酸罗哌卡因注射液对比,两者对局部皮肤创伤愈合的影响无明显的差别.