溶栓治疗对急性心肌梗死患者血浆ET-1、hs-CRP、TXA2、NO水平的影响

摘要

Objective To study the effect of thrombolytic therapy patients on plasma endothelin - 1 (ET - 1), high sensitive C - reactive protein (hs- CRP), thromboxane A2 (TXA2), nitric oxide (NO) levels in patients (pts) acute myocardial infarction(AMI).Methods Thirty - two pts with AMI were treated with urokinase,and then divided into recanalization group and non - recanalization group. The levels of plasma ET- 1, NO, hs - CRP, TXA2 were measured. Results The levels of plasma ET - 1, hs - CRP, TXA2 in treatment group were higher(P＜0.05) ,and NO level was lower than that in the control group(P＜0.05). The levels of plasma ET- 1,NO, hs- CRP, and TXA2 in recanalization group were significantly increased, and the peak was higher than that in non- recanalization group(P＜0. 05). The peak values of ET - 1, hs - CRP, TXA2, and NO in recanalization group were at 3 h after thrombolysis, and that in non- recanalization group were at 5 h after thrombolysis. Conclusion ET - 1, hs - CRP, TXA2 and NO could be used as index for thrombolytic therapy in AMI.%目的 探讨溶栓治疗对急性心肌梗死(AMI)患者血浆内皮素(ET-1)、超敏C反应蛋白(hs-CRP)、血栓素A2(TXA2)、一氧化氮(NO)水平的影响及其临床意义.方法 病例组32例,采用尿激酶溶栓治疗,分别测出溶栓前后再通组和未通组ET-1、NO、hs-CRP、TXA2水平的动态变化.正常对照组测空腹ET-1、NO、hs-CRP、TXA2水平.结果 病例组ET-1、hs-CRP、TXA2水平高于正常对照组(P<0.05),NO水平低于正常对照组(P<0.05);溶栓再通组的ET-1、NO、hs-CRP、TXA2水平显著增高,且峰值显著高于溶栓未通组的峰值(P<0.05);再通组ET-1、hs-CRP、TXA2和NO峰值提前,都在溶栓后3 h,而溶栓未通组峰值均为溶栓后5 h.结论 ET-1、hs-CRP、TXA2和NO相互作用,参与了AMI的循环炎症反应和再灌注损伤,可作为判断AMI病情及溶栓治疗再通的可能指标.