目的:探讨IgA肾病(IgAN)患者血液、尿液中单核细胞趋化蛋白-1(MCP-1)的含量变化及其临床意义.方法:将125例患者分为两组,即大量蛋白尿组和小量蛋白尿组,选取20例正常人为对照组.采用酶联免疫吸附法对实验组及对照组血液、尿液MCP-1的含量进行检测,同时测定患者的24 h尿蛋白定量和肾功能.结果:IgAN患者尿液中MCP-1的含量明显增高,大量蛋白尿组高于小量蛋白尿组和对照组.而IgAN患者血液MCP-1的含量与对照组比较差异无统计学意义.结论:IgAN的发病与趋化因子MCP-1有关.%Objective: To study the change of concentration and clinical significance of serum and unrine monocyte chemoattractant protein - 1 in patients with IgA nephropathy. Methods: 125 patients with IgA nephropathy were divided into macroalbuminuria group and microalbuminuria group,while 20 normal cases were chosen as control group. The ELSIA was employed to test the level of serum and urine MCP - 1 of the experimental group and the control group meanwhile the 24 - hour urinary protein ane renal function of all the patients were determined. Results :The urine concentration of MCP- 1 in patients with IgA increased remarkably. The concentration of macroalbuminuria group was higher than both the microalbuminuria group and control group. The microalbuminuria group was higher than the control group. There was no significant difference between the experimental and control group in serum MCP - 1 concentration. Conclusion: MCP - 1 is related with the pathogeny of IgA nephropathy.
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