化学发光法检测慢性乙型肝炎病毒感染者肝纤维化四项指标结果分析

摘要

Objective; To study the clinical value of hepatic fibrosis by using chemiluminescence immunoassays to detect the hyaluronic (HA), laminin (LN), type Ⅲ procollagen aminopeptide (PIIINP), collagen (C-W) .Methods: The four markers of hepatic fibrosis of 196 case were detectived by chemiluminescence immunoassays, included HBV carries 50 case, chronic hepatics B 48 case, chronic sever hepatic 36 case, cirrohosis 62 case. Results: There were significant difference among HBV carries, chronic hepatics B, chronic sever hepatic, and cirrohosis and the degreement of clinical value were; chronic sever hepatic > cirrohosis > chronic hepatics B > HBV carries . Conclusion: Chemiluminescence immunoassays is valuable methed for diagnostic analysis of hepatic fibrosis degree in liver chronic disease.%目的:探讨应用化学发光法定量检测肝纤维化指标透明质酸(HA)、层粘连蛋白(LN)、Ⅲ型前胶原氮端肽(PⅢNP)、Ⅳ型胶原(C-Ⅳ)对肝纤维化的诊断价值.方法:应用化学发光法检测196例慢性乙型肝炎病毒(HBV)感染者血清肝纤维化指标,其中HBV携带者50例,慢性乙型肝炎(CHB) 48例,慢性重型肝炎(简称慢重肝)36例,乙型肝炎肝硬化62例,正常对照40例,并对结果进行统计学分析.结果:患者HA、LN、PⅢNP、C-Ⅳ在HBV携带者、CHB、慢重肝、乙型肝炎肝硬化患者之间比较,差异有显著性意义(P＜0.05).测定值升高的顺序为:慢重肝＞乙型肝炎肝硬化＞ CHB＞ HBV携带者.结论:应用化学发光法动态检测肝纤维化四项指标是指导临床判断肝纤维化程度的非损伤性的良好检测方法.