原癌基因Pokemon在原发性肝癌患者外周血中的表达及意义

摘要

Objective:To investigate the expression and clinical significance of proto-oncogene Pokemon in serum of patients with hepatocellular carcinoma.Methods:The expression of Pokemon in 84 cases of hepatocellular carcinoma,40 cases of hepatic cirrhosis and 20 cases of healthy controls were detected by enzyme-linked immunosorbent assay (ELISA).Results:The serum level of Pokemon in HCC was higher than these in the hepatic cirrhosis and healthy people (P ＜ 0.05).The expression of Pokemon was closely related to the size of tumor and distant metastasis,but no correlation with AFP.Conclusion:Pokemon may become a new effective marker in the diagnosis of HCC,meanwhile the expression level of Pokemon may be useful to predict the size of tumor and distant metastasis.%目的:探讨Pokemon在原发性肝癌(HCC)患者外周血中的表达及临床意义.方法:收集肝癌患者84例,肝硬化患者40例,健康对照者40例,采用酶联免疫吸附试验(ELISA)测定3组人员血清Pokemon浓度.结果:肝癌患者血清中Pokemon表达量明显高于肝硬化患者和健康人,差异有统计学意义(P＜0.05)；Pokemon的表达量与肿瘤大小及有否远处转移相关,与AFP无相关性.结论:Pokemon可作为新的肿瘤标记物在肝癌诊断中起到积极作用,同时对预测肿瘤大小及远处转移有一定的临床价值.