慢性乙肝病毒携带者中医体质类型与T淋巴细胞亚群相关性研究

摘要

Objective:To investigate the correlation between chronic hepatic B virus (HBV) carriers' TCM constitution types and T-lymphocyte subpopulations. Methods:According to the criteria of nine kinds of constitutions drawed by professor WANG QI, 43 chronic HBV carriers had been selected from normal constitution, Qi-deficiency constitution, Yang-deficiency constitution and Yin-deficiency constitution, whose T-lymphocyte subpopulations were observed by statistical analysis of the percentage , absolute counts and the ratio of T cell subsets. Results:Compared with the normal constitution chronic HBV carriers, the percentage of CD4+ in the Yang-deficiency constitution was significantly decreased (P < 0. 05); the percentage of CD8+ in the Yang-deficiency constitution chronic HBV carriers was significantly higher than those in normal constitution, Qi-deficiency constitution and Yin-deficiency constitution ( P < 0. 05, < 0. 05 , < 0. 01 ) ; compared with the normal constitution chronic HBV carriers, the ratio of CD4+ and CD8 + in the Yang-deficiency constitution was significantly decreased (P < 0. 05) . The percentage of CD4+ in Yin-deficiency constitution chronic HBV carriers was significantly higher than those in the normal constitution, Qi-deficiency constitution and Yang-deficiency constitution (P <0. 05, <0. 01, <0. 01); and compared with the normal constitution, Qi-deficiency constitution and Yang-deficiency constitution, the absolute count of CD4 + in Yin-deficiency constitution chronic HBV carriers was significantly increased ( P < 0. 01, < 0.05, < 0. 01) . The ratio of CD4 + and CD8 + in the Yin-deficiency constitution chronic HBV carriers was significantly higher than those in the Qi-deficiency constitution and Yang-deficiency constitution (both P <0. 01) . But the absolute counts of CD8 + in the four kinds of TCM constitutions chronic HBV carriers showed no significant differences. Conclusion:The differences of the percentage, absolute count and the ratio of CD4 + and CD8 + can reflect the diversities of the immune states among various TCM constitution chronic HBV carriers, which will providernscientific guidances for the prevention and therapy of disease development in chronic HBV carriers.%目的:探讨慢性乙肝病毒(HBV)携带者中医体质类型与T淋巴细胞亚群的相关性.方法:根据王琦教授九种体质的判定标准,选择平和质、气虚质、阳虚质和阴虚质慢性HBV携带者43例进行T淋巴细胞亚群检测,分别对T细胞亚群的百分率、绝对计数和CD4 +/CD8+比值进行统计分析.结果:阳虚质者CD4+百分率较平和质有明显降低(P＜0.05),CD8+百分率较平和质、气虚质、阴虚质明显升高(P＜0.05、＜0.05、＜0.01),CD4+/CD8+比值较平和质明显降低(P＜0.05)；阴虚质的CD4+百分率较平和质、气虚质、阳虚质明显升高(P ＜0.05、＜0.01、＜0.01),阴虚质的CD4+绝对计数较平和质、气虚质、阳虚质明显升高(P ＜0.01、＜0.05、＜0.01),阴虚质的CD4 +/CD8+比值较气虚质、阳虚质明显升高(均P＜0.01)；4种中医体质慢性HBV携带者CD8+绝对值计数组间比较差异无统计学意义.结论:CD4+、CD8+T细胞及CD4+/CD8+比值的差异可以在一定程度上反映不同中医体质慢.性HBV携带者免疫状态,可科学地指导慢性HBV携带者临床防治.