以N,N'-二(4-甲氧基水杨基)丙烷-1,3-二胺为配体的三核钴(Ⅱ)和镍(Ⅱ)配合物的合成、结构及抗菌活性研究

摘要

本文合成了1个新的三核钴(Ⅱ)配合物[Co{CoL(μ2-CH3COO)}2] (1)和1个新的三核镍(Ⅱ)配合物[Ni {NiL(μ2-NO3)(CH3OH)}2](2),其中L代表去质子化的N,N’-二(4-甲氧基水杨基)丙烷-1,3-二胺.通过理化手段和单晶X-射线衍射表征了它们的结构.2个化合物都是中心对称的三核配合物.配合物1中的桥连基团为酚羟基氧原子和醋酸根;配合物2中的桥连基团为酚羟基氧原子和硝酸根.通过MTT比色法研究了配合物对枯草杆菌,金黄色葡萄球菌,大肠杆菌和荧光假单孢菌的抗细菌活性以及对白色念珠菌和黑曲霉的抗真菌活性.%Cobalt(H)complex [Co{CoL(μ2-CH3COO)}2] (1) and nickel(Ⅱ)complex [Ni{NiL(μ2-NO3)(CH3OH)}2] (2),where L is the deprotonated form of N,N'-bis(4-methoxysalicylidene)propane-1,3-diamine,have been synthesized and characterized by physico-chemical methods and single crystal X-ray diffraction.Both complexes are centrosymmetric trinuclear compounds.The bridging groups in [Co{CoL(μ2-CH3COO)}2] are phenolate O andμ2-acetate ligands,and those in [Ni{NiL(μ2-NO3)(CH3OH)}2] are phenolate O and μ2-nitrate ligands.The complexes were evaluated for their antibacterial (Bacillus subtilis,Staphylococcus aureus,Escherichia coli,and Pseudomonas fluorescence) and antifungal (Candida albicans and Aspergillus niger) activities by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) method.CCDC:736569,1; 736568,2.