自噬在急性胰腺炎发生发展中的作用

摘要

急性胰腺炎(AP)的发病是一个复杂的、多因素介导的病理生理过程,各因素间既相互独立又相互影响,至今尚未完全阐明.自噬广泛存在于真核生物的多种生命现象中,贯穿于正常细胞的生长发育和病理、生理过程.自噬在AP早期胰腺腺泡细胞损伤及其发生、发展中发挥着重要作用,但其在AP中的作用机制仍存在争议.鉴于此,本文对自噬在AP发生发展中的作用研究进展做一综述,以期为其发病机制的深入理解提供参考.%The onset of acute pancreatitis (AP) is a complex pathophysiological process mediated by multifactors which are not only interdependent but also influencing each other.So far,the specific molecular mechanism remains uncertain.Autophagy widely exists in a variety of vital phenomena in eukaryotes including the growth,development and pathophysiological progression of normal cells.Autophagy plays an important role in the early damage of acinar cells as well as the development of AP.However,the mechanism is still in doubt.Thus,we overviewed the role of autophagy in the occurrence and progression of AP in order to further enrich the understanding on the pathogenesis.