莫沙必利在老年人胶囊内镜检查中的作用

摘要

Objective To explore the effect of oral mosapride on gastrointestinal transit time in elderly patients undergoing capsule endoscopy.Methods A total of 61 patients referred for capsule endoscopy during 2010 September to 2012 January were involved in this study.40 patients over 65 years old were prospectively randomized into mosapride citrate group (n=19) or non-mosapride citrate group (n=21).Patients under 65 years old were in control group (n=21).Mosapride citrate group took 10 mg mosapride citrate orally before endoscopy.The gastrointestinal transit time was calculated.Results Gastric emptying time and small intestinal transit time of patients over 65 years old were significantly shorter in mosapride citrate group than in non-mosapride citrate group [(48.6± 21.1) minand (64.3±22.4) min,t=2.274,P=0.029; (302.2±67.6) min vs.(347.14±51.18) min,t=2.384,P=0.022].There were on significant differences in gastric emptying time and small intestinal transit time between non-older group [(45.4 ± 28.4) min and (284.8 ± 78.3) min] and mosapride citrate group (t=0.407,P=0.686;t=0.751,P=0.457).There was a difference in the image score between medication group and no medication group (4.94±0.63 versus 4.50±0.68; t=2.137,P=0.039) in over 65 years old patients.Conclusions Mosapride may decreased the gastric emptying time and small intestinal transit time,improves the capsules endoscopy image quality and testing completion rate.%目的 探讨应用莫沙必利对老年患者胶囊内镜检查中胃肠转运时间的影响. 方法 2010年9月至2012年1月间因疑似小肠疾病的患者61例,其中年龄≥65岁者40例,随机分为老年服药组19例和老年对照组21例,年龄＜65岁者21例为非老年对照组.服药组胶囊内镜检查前口服促胃肠动力药莫沙比利10 mg,记录胶囊内镜的胃肠通过时间. 结果 老年服药组胃及小肠通过时间分别为(48.6±21.1) min和(302.2±67.6) min,老年对照组分别为(64.3±22.4) min和(347.1±51.2) min,两组差异有统计学意义(t胃=2.274,P胃=0.029;t肠=2.384,P肠=0.022).非老年对照组胃及小肠通过时间分别为(45.4±28.4)min和(284.8±78.3)min,与老年服药组比较,差异无统计学意义(t胃=0.407,P胃=0.686;t肠=0.751,P肠=0.457).老年服药组和老年对照组图像评分分别为(4.94±0.63)分和(4.50±0.68)分,差异有统计学意义(t=2.137,P=0.039). 结论 老年患者胶囊内镜检查前口服莫沙必利药能缩短胶囊胃肠通过时间,改善胶囊镜的图像质量,提高检查完成率.